121. A 50-year-old lady presented with a 3 moth history of pain in the lower third of the right thigh. There was no local swelling; tenderness was present on deep pressure. Plain X-rays showed an ill-defined intra medullary lesion with blotchy calcification at the lower end of the right femoral diaphysis, possibly enchondroma or chondrosarcoma. Sections showed a cartilaginous tumour. Which of the following histological features (if seen) would be helpful to differentiate the two tumours?
1. Focal necrosis and lobulation
2. Tumour permeationbetween bone trabeculae at periphery.
3. Extensive myxoid change
4. High cellularity
Ans. -2
122. The differential diagnoses of lesion, histologically resembling giant cell tumour in the small bones of the hands or feet, includes all of the follwing except:
1. Aneurysmal bone cyst
2. Fibrosarcoma
3. Osteosarcoma
4. Hyperparathyroidism
Ans. -*
123. As regards to intraocular retinoblastoma, which one of the following statements is false?
1. 94% of cases are sporadic
2. Patients with sporadic retinoblastoma do not pass their genes to their offsprings.
3. Calcificatinin thetumor can be detected on ultrasound scan
4. Presence of extraocular extension
Ans. -*
124. Which of the following is not of prognostic significance in choroidal melanoma?
1. Presence of retinal detachment
2. Size of the tumor
3. Cytology of the tumor cells
4. Presence of extraocular extension
Ans. -3
125. Which of the following hemoglobin (Hb) estimation will be diagnostically helpful ina case of beta thalassemia trait?
1. Hb-F
2. Hb-A1C
3. Hb-A2
4. Hb-H
Ans. -4
126. Appropriate material for antenatal diagnosis of genetic disorders include all of the following except:
1. Fetal blood
2. Amniotic fluid
3. Chorionic villi.
4. Maternal urine.
Ans. -2
127. Which of the following statements about carcinogenesis is false?
1. Asbestos exposure increases the incidence of lung cancer
2. Papilloma viruses produce tumours in animals but not in humans
3. Exposure to aniline dyes predisposes to cancer of the urinary bladder.
4. Hepatitis B virus has been implicated in hepatocellular carcinoma
Ans. -3
128. Which of the following is an example of disorders of sex chromosomes?
1. Marfan’s syndrome
2. Testicular feminization syndrome
3. Klinefelter’s syndrome
4. Down’s syndrome
Ans. -4
129. Which of the following statements on lymphoma is not true?
1. A single classification system for Hodgkin’s disease (HD) is almost universally accepted
2. HD more often tends to remain localized to a single group of lymph nodes and spreads by contiguity
3. Several types of non hodgkins lymphoma (NHL) may have a leukemic phase.
4. In general, follicular (nodular) NHL has worse prognosis compared to diffuse NHL.
Ans. -3
130. Which of the following is characteristically not associated with the development of interstitial lung disease?
1. Organic dusts
2. Inorganic dusts
3. Toxic gases e.g. chlorine, sulphur dioxide
4. Inhalation of tobacco smoke
Ans. -3
1. Focal necrosis and lobulation
2. Tumour permeationbetween bone trabeculae at periphery.
3. Extensive myxoid change
4. High cellularity
Ans. -2
122. The differential diagnoses of lesion, histologically resembling giant cell tumour in the small bones of the hands or feet, includes all of the follwing except:
1. Aneurysmal bone cyst
2. Fibrosarcoma
3. Osteosarcoma
4. Hyperparathyroidism
Ans. -*
123. As regards to intraocular retinoblastoma, which one of the following statements is false?
1. 94% of cases are sporadic
2. Patients with sporadic retinoblastoma do not pass their genes to their offsprings.
3. Calcificatinin thetumor can be detected on ultrasound scan
4. Presence of extraocular extension
Ans. -*
124. Which of the following is not of prognostic significance in choroidal melanoma?
1. Presence of retinal detachment
2. Size of the tumor
3. Cytology of the tumor cells
4. Presence of extraocular extension
Ans. -3
125. Which of the following hemoglobin (Hb) estimation will be diagnostically helpful ina case of beta thalassemia trait?
1. Hb-F
2. Hb-A1C
3. Hb-A2
4. Hb-H
Ans. -4
126. Appropriate material for antenatal diagnosis of genetic disorders include all of the following except:
1. Fetal blood
2. Amniotic fluid
3. Chorionic villi.
4. Maternal urine.
Ans. -2
127. Which of the following statements about carcinogenesis is false?
1. Asbestos exposure increases the incidence of lung cancer
2. Papilloma viruses produce tumours in animals but not in humans
3. Exposure to aniline dyes predisposes to cancer of the urinary bladder.
4. Hepatitis B virus has been implicated in hepatocellular carcinoma
Ans. -3
128. Which of the following is an example of disorders of sex chromosomes?
1. Marfan’s syndrome
2. Testicular feminization syndrome
3. Klinefelter’s syndrome
4. Down’s syndrome
Ans. -4
129. Which of the following statements on lymphoma is not true?
1. A single classification system for Hodgkin’s disease (HD) is almost universally accepted
2. HD more often tends to remain localized to a single group of lymph nodes and spreads by contiguity
3. Several types of non hodgkins lymphoma (NHL) may have a leukemic phase.
4. In general, follicular (nodular) NHL has worse prognosis compared to diffuse NHL.
Ans. -3
130. Which of the following is characteristically not associated with the development of interstitial lung disease?
1. Organic dusts
2. Inorganic dusts
3. Toxic gases e.g. chlorine, sulphur dioxide
4. Inhalation of tobacco smoke
Ans. -3
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