111. All of the following are true of beta thalassemia major except
1. Splenomegaly
2. Target cells on peripheral smear
3. Microcytic hypochromic anemia
4. Increased osmotic fragility
Ans. -4
112. A couple has two children affected with tuberous sclerosis. On detailed clinical and laboratory evalution (including molecular studies) both parents are normal. Which one of the following explains the two affected children in this family?
1. Non penetrance
2. Uniparental diasomy
3. Genomic imprinting
4. Germline mosaicism
Ans. -4
113. Conjugated hyperbilirubinemia is seen in
1. Gilbert’s syndrome
2. Criggler Najjar syndrome
3.Brest
4. Dubin Johnson syndrome
Ans. -2
114. Which of the following does not establish a diagnosis of congenital CMV infection in a neonate?
1. Urine culture of CMV
2. IgG CMV antibodies in hepatocytes
3. Intra-nuclear inclusionbodies in hepatocytes
4. CMV viral DNA in blood by polymerase chain reaction
Ans. -4
115. In a child with acute liver failure, the most important prognostic factor for death is:
1. Increasing transaminases
2. Increasing Bilirubin
3. Increasing prothrombin time
4. Gram negative sepsis
Ans. -3
116. Which of the following circulating antibodies has the best sensitivity and specificity for the diagnosis of celiac disease?
1. Anit-endomysial antibody
2. Anti-tissue transglutaminase antibody
3. Anti-gliadin antibody
4. Anti-reticulin antibody
Ans. -4
117. A 45-year-old male having a long history of cigarette smoking presented with gangrene of left foot. An amputation of the left foot was done. Representative sections from the specimen revealed presence of arterial thrombus with neutrophilic infiltrate in the arterial wall. The inflammation also extended into the neighboring veins and nerves. The most probable diagnosis is:
1. Takayasu arteritis.
2. Giant cell arteritis
3. Hypersensitivity angiitis
4. Thromboangitis obliterans
Ans. -1
118. A 50-year-old male presented with signs and symptoms of restrictive heart disease. A right ventricular endo-myocardial biopsy revealed deposition of extra cellular eosinophilic hyaline material. On transmission electron microscopy, this material is most likely to reveal the presence of :
1. on branching filaments of indefinitive length
2. Cross banded fibres with 67 nm periodicity.
3. Weber Palade bodies.
4. Concentric whorls of lamellar structures
Ans. -3
119. An undifferentiated malignant tumour on immunohistochemical stain shows cytoplasmic positivity of most of the mtumour cell for cytokeratin. The most probable diagnosis of the tumour is:
1. Sarcoma.
2. Lymphoma.
3. Carcinoma
4. Malignant Melanoma
Ans. -3
120. Sections from a solid-cystic unilateral ovarian tumour in 30 year old female show a tumour composed of diffuse sheets of small cells with doubtful nuclear grooving and scanty cytoplasm. No Call-Exner bodies are seen. The ideal immunohistochemistry panel would include:
1. Vementin, epithelial membrane antigen, inhibin, CD99
2. Desmin, S- 100 protein, smooth muscle antigen, cytokeratin
3. Chromogranin, CD 45, CD 99, CD 20
4. CD 3, chromagranin, Cd 45, synaptophysin
Ans. -1
1. Splenomegaly
2. Target cells on peripheral smear
3. Microcytic hypochromic anemia
4. Increased osmotic fragility
Ans. -4
112. A couple has two children affected with tuberous sclerosis. On detailed clinical and laboratory evalution (including molecular studies) both parents are normal. Which one of the following explains the two affected children in this family?
1. Non penetrance
2. Uniparental diasomy
3. Genomic imprinting
4. Germline mosaicism
Ans. -4
113. Conjugated hyperbilirubinemia is seen in
1. Gilbert’s syndrome
2. Criggler Najjar syndrome
3.
4. Dubin Johnson syndrome
Ans. -2
114. Which of the following does not establish a diagnosis of congenital CMV infection in a neonate?
1. Urine culture of CMV
2. IgG CMV antibodies in hepatocytes
3. Intra-nuclear inclusionbodies in hepatocytes
4. CMV viral DNA in blood by polymerase chain reaction
Ans. -4
115. In a child with acute liver failure, the most important prognostic factor for death is:
1. Increasing transaminases
2. Increasing Bilirubin
3. Increasing prothrombin time
4. Gram negative sepsis
Ans. -3
116. Which of the following circulating antibodies has the best sensitivity and specificity for the diagnosis of celiac disease?
1. Anit-endomysial antibody
2. Anti-tissue transglutaminase antibody
3. Anti-gliadin antibody
4. Anti-reticulin antibody
Ans. -4
117. A 45-year-old male having a long history of cigarette smoking presented with gangrene of left foot. An amputation of the left foot was done. Representative sections from the specimen revealed presence of arterial thrombus with neutrophilic infiltrate in the arterial wall. The inflammation also extended into the neighboring veins and nerves. The most probable diagnosis is:
1. Takayasu arteritis.
2. Giant cell arteritis
3. Hypersensitivity angiitis
4. Thromboangitis obliterans
Ans. -1
118. A 50-year-old male presented with signs and symptoms of restrictive heart disease. A right ventricular endo-myocardial biopsy revealed deposition of extra cellular eosinophilic hyaline material. On transmission electron microscopy, this material is most likely to reveal the presence of :
1. on branching filaments of indefinitive length
2. Cross banded fibres with 67 nm periodicity.
3. Weber Palade bodies.
4. Concentric whorls of lamellar structures
Ans. -3
119. An undifferentiated malignant tumour on immunohistochemical stain shows cytoplasmic positivity of most of the mtumour cell for cytokeratin. The most probable diagnosis of the tumour is:
1. Sarcoma.
2. Lymphoma.
3. Carcinoma
4. Malignant Melanoma
Ans. -3
120. Sections from a solid-cystic unilateral ovarian tumour in 30 year old female show a tumour composed of diffuse sheets of small cells with doubtful nuclear grooving and scanty cytoplasm. No Call-Exner bodies are seen. The ideal immunohistochemistry panel would include:
1. Vementin, epithelial membrane antigen, inhibin, CD99
2. Desmin, S- 100 protein, smooth muscle antigen, cytokeratin
3. Chromogranin, CD 45, CD 99, CD 20
4. CD 3, chromagranin, Cd 45, synaptophysin
Ans. -1
No comments:
Post a Comment