76 - NIMS MEDICINE february 2009 paper - 1

1q: antineutrophilic cytoplasmic ( ANCA ) antibodies are seen in all except ?

a. churg strauss syndrome
b. wegener's granulomatosis
c. microscopic polyangitis
d. polyarteritis nodosa

answer: d . polyarteritis nodosa .

antineutrophilic cytoplasmic antibodies are of two types

1. P - ANCA = perinuclear antineutrophilic cytoplasmic antibodies and

2. C - ANCA = antineutrophilic cytoplasmic antibodies directed against cytoplasmic proteinase-3

the causes of P - ANCA are

a. microscopic polyangitis ( microscopic PAN )
b. churg strauss syndrome
c. cresentric glomerulonephritis
d. good pasture syndrome
e. rarely seen in classic PAN

the causes of C - ANCA are

a. wegener's granulomatosis .